Research Project Proposal Academic year ‐ Project Nº 53 Title: Antimicrobial peptides to control biofilms associated with medical implants Department/ Laboratory: Department of Microbiology and Parasitology; School of Medicine Director: Guillermo Martínez de Tejada de Garaizábal ANTIMICROBIAL STEWARDSHIP PROGRAM PROPOSAL SAMPLE. Background Currently, the antimicrobial expenses at HOSPITAL, excluding antiretroviral medications, is approximately million dollars per year, in the acute care setting. $XX Another $XXX is being spent annually in the outpatient setting. However, there are PROJECT PROPOSALS Institut Pasteur, France / 29 February GLOBAL ANTIBIOTIC RESEARCH AND DEVELOPMENT (GARD) PARTNERSHIP Developing new antibiotic treatments, promoting responsible use, and ensuring access for all A joint WHO/DNDi initiative incubated by DNDi in support of the Global Action Plan for Antimicrobial Resistance
Research Proposal Sample – Antibiotic Resistance
Antibiotic resistance is one of the major threats to modern medical practices, as medical practices rely upon the convenience of antimicrobial drugs that can treat and prevent infections in animals and humans. Each year there are more than 2 million people who acquire bacterial infections that may develop resistance to two or more antibiotics that are designed to kill these infections Mykietiuk et al, According to studies, approximately 24, people die each year due to this antibiotic resistance infection, and also many dies due to complications which develop due to theses antibiotic resistance infection Mykietiuk et al, This antibiotic resistance has attributed to the misuse or overuse of these drugs, antimicrobial research proposal, in addition to this, there is also a lack of development of new drugs by pharmaceutical companies because of challenging regulatory requirements and also because of less economic incentives, antimicrobial research proposal.
This research aims to describe the role of broad spectrum antibiotics on fighting with this antibiotic resistance. Broad spectrum antibiotics are used to treat infections that are resistance to narrow spectrum antibiotic or top the infection which does not respond to other drugs.
Broad spectrum antibiotics are active against both gram negative and gram positive organisms, these drugs include fluoroquinolones, tetracycline, cephalosporin, and phenols. The antibiotics are not only used to treat infectious diseases but also undermine the treatment of the complications which may occur due to these infections.
In advance, antimicrobial research proposal, medical treatment such as chemotherapy for cancer patients, joint replacement procedures, antimicrobial research proposal, kidney dialysis, antimicrobial research proposal, and other chronic disease requires the effective antibiotics to fight against the resistant infections.
Modern medical practice largely depends on the use of an antibiotic. Development of antibiotic resistance can lead to a number of complications that needs assessment and proper evaluation. As with the advent of modified forms of antibiotics, infections are also modified to develop resistance to these antibiotics Landecker Penicillin was first prescribed to treat infections during Second World War, after sometimes resistance against penicillin developed for which there was the advent of Beta- Lactam antibiotics, and so on with the development of one drug there was also the development of resistance against it for which new drugs should be introduced.
Antibiotic resistance mainly develops due to overuse or misuse of drugs. Therefore, there is a need of proper guidance for health care practitioners before prescribing any antibiotic to their patients.
Lewis poured some light on the discovery of antibiotics. According to this study, the golden era of discovery of antibiotics was the s to s. Also, it focuses on the spread of new bacteria which can develop resistance to these antibiotics, antimicrobial research proposal, so far Beta-Lactams are the most successful intervention in medical history that can help to deal with the chronic infections and also with the antimicrobial research proposal which develops against the antibiotics.
Ventola lightened the history antimicrobial research proposal antibiotic resistance and also the factors which cause this resistant. According to this study, the crisis of antibiotic resistance is a global issue, which needs proper assessment. It focuses on the need of development of new drugs that can help to deal with antibiotic-resistant infections. There are seven main factors that should be evaluated: availability of antibiotic, transmissibility, clinical impact, incidence, economic impact, and also to barriers to prevent the disease.
Resistance Microbes including the antimicrobial drugs are moving their attention into wide range of reservoirs such as flora, human, antimicrobial research proposal, fauna, environment etc. These reservoir are becoming the tenacious substrate for microbes to start breeding and also spread widely through variety of different factors.
Unfortunately the emergence of a superbugs that are also knowns as strains of bacteria that has an ability to resist more than one type of antibiotic. This has increased the number of people who are killed each year because of the development of resistance against a drug or due to the complication which may occur because of this antibiotic resistant infection.
In order to treat the superinfections, the broad spectrum antibiotic is very useful, as this spectrum of drugs allows to begin the treatment without identifying the bacteria. The purpose of this research is to describe the importance of the impact of Broad spectrum antibiotics to fight with the antibiotic resistance. It also focuses the attention of the practitioners to design a drug that is more compatible to kill antibiotic-resistant infections.
The aim of this research is to investigate the impact of the broad-spectrum drug to fight Antibiotic resistance. H 1 : There is an insignificant positive relationship between broad spectrum antibiotics to fight against antibiotic resistance, antimicrobial research proposal.
H 0 : There is a significant negative relationship between broad spectrum antibiotics to fight against antibiotic resistance. H 1 : There is an insignificant negative relationship between broad spectrum antibiotics to fight against antibiotic resistance. Theoretical and empirical studies have explained the emergence of resistance to antibiotics, it is a matter of global consideration as it affects not only the hospitals but also to the whole community.
There are various factors that can results in development of antibiotic resistance such as overuse or misuse of the antibiotics, hospitals are one of the vulnerable place which has high concentration of ill patients that can develop antimicrobial resistance in very short period of time, antimicrobial research proposal. In order to reduce the antibiotic resistance there are two different approaches which can be adopted, one is switching to other drug and second is reducing the use of that antibiotic.
Studies draw the attention towards the action of peptides that have broad spectrum activity against some virus, antimicrobial research proposal, bacteria, parasites and fungi Barbosa and Levy, To overcome this challenges there is a need for designing the drug that can optimize the activity of drug-resistant infections.
There are different types of broad spectrum peptides that are designed to combat this antimicrobial resistance, such as bovine neutrophil cationic peptide is one of the smallest occurring broad-spectrum peptides, it works by the internal disulfide bridge and has activity against gram-negative bacteria Cherkasov et al, Despite this research, pharmaceutical companies should focus more on developing other drugs that can help in combating against the antibiotic resistance.
Evidence have shown that there is the positive impact of drugs that has an antimicrobial effect Payne et al, Patel also highlighted the understanding and responding to antimicrobial research proposal emergency crisis for antibiotic resistance. It shows that the modern medical practice is in constant need for the development of substrate that has an ability to combat against this antibiotic resistance.
It is mainly because the bacterial species readily develop resistant against one type of drug and may not respond to its substitutes. This shows advancement in pharmaceutical companies is required to generate new peptides, amino acid, antimicrobial research proposal, or cellulose substrates that have an ability to break antimicrobial research proposal disulfide bridge of virus or bacteria. The alarming stage for this biofilm infection is that they are highly resistant to conventional antibiotics, there is various broad spectrum antibiotic which works on the synergetic action with other drugs to combat against these antibiotic resistant infections Rodríguez, antimicrobial research proposal, This anti-biofilm peptide has a synergistic action with broad spectrum antibiotic which includes ciprofloxacin, imipenem, ceftazidime, or tobramycin.
Theses evidence have shown the importance of designing the broad spectrum drug to fight against antibiotic resistance. Antibiotics are made by undergoing a process of testing in a laboratory. Firstly, antibiotic microbes are allowed to grow in the flasks, which are then transferred antimicrobial research proposal large fermentation vats.
After this antimicrobial research proposal, the antibiotic is extracted from the microbe culture and then finally gets purified. To check the activities of broad spectrum drug against antibiotic-resistant infections. Antimicrobial research proposal have developed different methods such as using different culture that show the activity of the drug against infection, using peptides such as silver nanoparticles that show the activity of the drug against resistant infection by reducing the growth rate of bacteria.
Moreover, Kirby-Bauer test is also used to track the bactericidal action against the microorganisms Lara et al. Mainly there are two types of research approach, one is deductive and another is inductive. The deductive approach aims to specify the general idea. However inductive approach is about generalizing the specific idea. In a deductive approach the premises are limited as a researcher is not allowed to antimicrobial research proposal from the specific concept and obligated to cater research gap and present an original conclusion.
In an inductive approach, known premises are used and the author is free from restrictions that are why the research findings can be generalized. Our research is deductive in nature as it focuses on the statistical sampling method. Qualitative and quantitative are the two research methods antimicrobial research proposal are most commonly used by the researchers. The third method is known as the mixed research method. Quantitative method refers top antimicrobial research proposal analysis of the gathered data that is collected from diverse data collection.
In this method statistical tools are used to interpret data and make conclusion, However, in qualitative research method inquiries are conducted on already available data for making logical conclusions. In this research mixed approach will be used to overcome the weakness of each method and also to gather a wider range of data and draw a sensible and authentic conclusion.
For the attainment of the objective of research the data will be gathered from both primary and secondary sources. Aim of the primary data collection method is to collect the current data on the specified issue. Once the approval will be gathered from different hospitals, the subjects will be provided survey questionnaires.
The quantitative data will be gathered through survey questioners that will be based on Likert scale. In addition to it, antimicrobial research proposal, qualitative data will be collected by using the instrument of observations, in terms of finding the reports of various hospitals. The purpose of the secondary data is to draw a conclusion based on the already existing material.
For data gathering, secondary sources that will be used includes literature reviews, general articles, new articles, antimicrobial research proposal, blogs, and websites, antimicrobial research proposal. For any research, it is essential to decide on the sample size of the research. For this research, it has been decided that the primary data will be gathered through survey questioners and approximately practitioners from 7 hospitals will be surveyed. However, antimicrobial research proposal, qualitative research will be done by observation.
Survey questionnaires will be distributed physically in 7 hospitals. Also in our research, we will be using probability sampling method in which simple random sampling is selected for collection of data. The observation will be done by setting the inclusion criterion on the subjects of adults patients aged under 21 to 50 years for knowing about the best antibiotic against infection. Nevertheless, the antimicrobial research proposal population is antimicrobial research proposal required for the research group, as this will significantly bring the outcomes for covering viral illnesses, which will eventually give the rationale of antibiotic resistance.
The rationale for choosing this sample size is because of less number of hospitals in the available location and also because of ineffective distribution of time of the practitioners. You must be logged in to post a comment.
Skip to content. Research Proposal Sample — Antibiotic Resistance. Introduction Antibiotic resistance is one of the major threats to modern medical practices, antimicrobial research proposal, as medical practices rely upon the convenience of antimicrobial drugs that can treat and prevent infections in animals and humans.
Background of the study Modern medical practice largely depends on the use of an antibiotic. Purpose of the research The purpose of this research is to describe the importance of the impact of Broad spectrum antibiotics to fight with the antibiotic resistance. Research Aim The aim of this research is to investigate the impact of the broad-spectrum drug to fight Antibiotic resistance. Research Objectives For the attainment of the aim of the research the objectives are as follow: To determine the importance of using broad spectrum drugs.
To explain the categorization of the antibiotics To determine the approach through which broad spectrum drug is helping to fight against antibiotic-resistant Research Questions What is the importance of broad spectrum drug in fighting bacterial resistance?
How broad spectrum drug helps in combating antibiotic-resistant infections? Hypothesis There is a significant positive antimicrobial research proposal between broad spectrum antibiotics to fight against antibiotic resistance. Literature Review Theoretical and empirical studies have explained the emergence of resistance to antibiotics, it is a matter of global consideration as it affects not only the hospitals but also to the whole community.
How we get broad spectrum antibiotics Antibiotics are made by undergoing a process of testing in a laboratory. After this process, the antibiotic is extracted from the microbe culture and then finally gets purified Monitoring activities Against Antibiotic Resistance Bacteria To check antimicrobial research proposal activities of broad spectrum drug against antibiotic-resistant infections, antimicrobial research proposal.
Methodology Overview of selected Methodology Approach: Deductive Methods: Mixed method qualitative and quantitative Instrument: Survey questionnaire and observations Sample Size: practitioners from 7 hospitals for questionnaire and patients of 21 to 50 years for observation Research Approaches Mainly there are two types of research approach, one is deductive antimicrobial research proposal another is inductive.
Research Methods Qualitative and quantitative are the two research methods that are most commonly used by the researchers. Data collection methods For the attainment of the objective of research the data will be gathered from both primary and secondary sources. Primary data collection Aim of the primary data collection method is to collect the current data on the specified issue.
Secondary data collection The purpose of the secondary data is to draw a conclusion based on the already existing material.
Antibiotic Resistance Proposal video
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Oct 10, · Antimicrobial Activity of Soil- Research Proposal. Microbes produce various antibiotics and by isolating different microbes the antibodies can be tested for. Soil samples are highly rich in microorganisms. The antimicrobial activities of microbes from 3 different soil sources (Tenby, Summerstrand, North Campus main building round-about and South Campus water pond) will be blogger.comted Reading Time: 12 mins Research Project Proposal Academic year ‐ Project Nº 53 Title: Antimicrobial peptides to control biofilms associated with medical implants Department/ Laboratory: Department of Microbiology and Parasitology; School of Medicine Director: Guillermo Martínez de Tejada de Garaizábal PROJECT PROPOSALS Institut Pasteur, France / 29 February GLOBAL ANTIBIOTIC RESEARCH AND DEVELOPMENT (GARD) PARTNERSHIP Developing new antibiotic treatments, promoting responsible use, and ensuring access for all A joint WHO/DNDi initiative incubated by DNDi in support of the Global Action Plan for Antimicrobial Resistance
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